Topiramate nephrotoxicity
Web1. máj 2007 · Topiramate (TPM) is a novel AED approved for the treatment of both partial and generalized epileptic seizures and for migraine headache . In a double-blind, placebo-controlled trial in healthy volunteers, we found that TPM (mean dose 330 mg/day) impairs performance on several cognitive tests . The magnitude of cognitive effect on measures … Web26. nov 2013 · Gemcitabine. Gemcitabine is also a cause of TMA, with a reported incidence ranging from 0.015 to 1.4% [ 42–44 ]. Based on a patient exposure of 78 800, Fung et al. [ 42] calculated a crude overall incidence rate of 0.015% (range, 0.008–0.078%), showing that HUS associated with gemcitabine treatment appears to be rare.
Topiramate nephrotoxicity
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Web1. aug 2024 · It emphasizes integrating our understanding of nephrotoxicity with pathological-induced renal failure. Such approaches are needed to address major questions in the field, which include the diagnosis, prognosis and treatment of both acute and chronic renal failure, and the progression of acute kidney injury to chronic kidney disease. ...
WebIntroduction: The clinical manifestations of acute topiramate toxicity are described. Methods: Seven cases of acute and acute-on-chronic topiramate toxicity observed in two clinical units of Polish Poison Control Centers in 2004-2005 were analyzed. Results: The patients were 4 women and 2 men aged between 16 and 38 (mean 21.0 +/- 8.4) years. WebTable 3 outlines the mechanism and nephrotoxicity of commonly encountered NTX in neonates. In older children NTX exposure has been shown to be a potentially modifiable …
Web19. júl 2008 · Topiramate, a voltage‐gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxicity. We … WebTopiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxicity. We investigated …
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WebTopiramate has multiple pharmacological mechanisms that are efficient in treating epilepsy and migraine. Ginger has been established to have gingerols and shogaols that cause migraine relief. Moreover, Topiramate has many off-label uses. Thus, it was necessary to explore the possible neurotoxicity o … dss community hubWeb18. júl 2016 · In dogs the most common causes of nephrotoxicosis are ethylene glycol (EG), nonsteroidal antiinflammatory drugs (NSAIDs), cholecalciferol (CCF), and aminoglycoside antibiotics. In cats the most common causes of nephrotoxicity are EG, CCF, and Easter lilies. An expanded list of known nephrotoxins is presented in Web Box 5-1. dss coins omaha neWebTopiramate and vitamin E have protective effects on pentylenetetrazol-induced nephrotoxicity by inhibition of free radicals and by support of the antioxidant redox system. Previous studies have shown that generation of free radicals is increased following pentylenetetrazol kindling, due to increased cytosolic Ca2+ concentrations. Topiramate, a … dss community first choiceWebtobramycin inhaled and topiramate both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicity. tolterodine.... commercialservices bedford.gov.ukWebIncreasing body of evidence indicates that topiramate possesses not only antiepileptic but also neuroprotective properties due to its multiple mechanisms of action. It has been reported, however, that it may cause adverse effects such as renal toxicity [11, 12] although there is no information of the effect of oxidative stress on renal toxicity. dsscomp_tsuchi_20220829.pdf hitachi.co.jpWeb29. júl 2024 · The mechanism of vancomycin-induced nephrotoxicity is uncertain and inadequately studied but may be related to injury to proximal tubule cells, with some evidence of interstitial nephritis . The risk of nephrotoxicity is increased 3- to 4-fold when vancomycin is combined with aminoglycosides and other nephrotoxic agents . Moreover, … commercial services analyticsWebC against topiramate-induced nephrotoxicity in male rats. According to our research in the litera-ture, there is no published data showing the anti-oxidant effects of vitamin C on topiramate-induced commercial services design holdings