WebbF-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00256
The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator …
Webb3.1.2.1 SKP1-Cullin 1-F-Box Protein (SCF) E3 Ligases. The SCF E3 ligases are composed of multiple subunits, namely the Skp I (S-phase kinase-associated protein (1), cullin, and F … Webb3 jan. 2024 · Background Skp1-Cullin-F-box (SCF) E3 ligase complex plays an important role in regulating spermatogenesis and fertility in mice. As a member of F-box proteins, … requirements for new irs agents
UniProt
Webb6 nov. 1998 · Skp1 interacts with cullins, F-box containing proteins, and forms a complex with cyclin A-Cdk2 in mammalian cells. Skp1 is also involved in diverse biological … Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation. Along with the anaphase-promoting complex, SCF has important roles in the ubiquitination of proteins involved in the cell … Visa mer SCF contains a variable F-box protein and three core subunits: • F-box protein (FBP) – FBP contributes to the substrate specificity of the SCF complex by first aggregating to target proteins … Visa mer The first hint that led to the discovery of the SCF complex came from genetic screens of Saccharomyces cerevisiae, also known as budding yeast. Temperature … Visa mer Recently, SCF complexes have become an attractive anti-cancer target because of their upregulation in some human cancers and their biochemically distinct active sites. Though many … Visa mer The eukaryotic cell cycle is regulated through the synthesis, degradation, binding interactions, post-translational modifications of regulatory proteins. Of these regulatory … Visa mer The plant hormone auxin binds Tir1 (Transport Inhibitor Response 1). Tir1 is an Auxin Signaling F-box Protein (AFB) that acts as an auxin receptor. Auxin-bound Tir1 stimulates … Visa mer WebbNumb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity; Glomulin binds Rbx1 and … requirements for new passport