WebSep 21, 2024 · The current limitations of naturally occurring AAV serotypes and artificially selected capsid variants obtained through molecular evolution create a high demand for synthetic, and improved AAV vectors for muscle gene therapy (and others) that are more specific, safer, and more efficacious than the present AAV variants while remaining … WebAAV can be used to transiently express a gene of interest in a variety of cell types. It was first described about 50 years ago as a contaminant of adenoviral preparations, hence the name ( Atchison et al., 1965 ) AAV is a single stranded, DNA virus belonging to the family Parvoviridae. It has a "simple" genome packaged in an icosahedral capsid ...
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