High affinity nerve growth factor receptor
WebTo study the effects of transfection of high-affinity nerve growth factor receptor gene (trkA) on NGF-induced differentiation of human neuroblastoma cell line IMR-32. …
High affinity nerve growth factor receptor
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Web1 de dez. de 2002 · High affinity NGF receptor (TrkA) (Fig. 4) was more expressed on MAX osteoarthritic chondrocytes (41.4±19%) than MIN osteoarthritic chondrocytes … Web1 de jan. de 2024 · Nerve growth factor (NGF) is produced and released in injured tissues or chronic pain tissues caused by other diseases. Studies have shown that monoclonal antibodies targeting NGF have a good efficacy in the treatment of osteoarthritis (OA), low back pain and chronic pain, which may be a promising therapy.
WebIn this study, we show that binding of nerve growth factor to its low affinity p75 neurotrophin receptor is essential to achieve the apoptotic response. Blockage of binding to p75 receptor neutralized nerve-growth-factor-induced cell death, as measured by immunoassays detecting the presence of cytosolic oligonucleosomes and by TUNEL … Webp75NTR is a member of the tumor necrosis superfamily of proteins which is variably associated with induction of apoptosis and proliferation. Cyclin D2 is one of the …
WebThe mechanisms that influence nerve growth are not known. Nerve growth factor (NGF) and its high-affinity tyrosine kinase receptor A (TrkA) are involved in neural … Web24 de nov. de 2004 · A high-affinity site, Site1, is always occupied first by the receptor ECD (R1) to form a stable 1:1 hormone-receptor intermediate complex [human GH …
WebOvarian cancer is the eighth most common cancer in women worldwide, and epithelial ovarian cancer (EOC) represents 90% of cases. Nerve growth factor (NGF) and its …
Web11 de dez. de 2000 · These molecules bind two types of cell surface receptors characterized by different binding affinities and molecular weight, including a 75-kD low-affinity glycoprotein receptor (p75) and 140- to 145-kD high-affinity receptors recognized by a tyrosine-specific protein kinase (Trk) activity. bison polymax witWeb1 de jun. de 2003 · NGF binds to the specific high-affinity tyrosine kinase receptor TrkA. TrkA receptors possess a tyrosine kinase catalytic domain. The structure of the TrkA-NGF complex has recently been published and contains one conserved motif, common to all neurotrophins, and one specific motif for TrkA-NGF binding (5). darren brookes life coachWeb7 de fev. de 2010 · High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. darren broughton facebookWeb1 de jul. de 1997 · Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system. NGF binds with high affinity to the extracellular region of the tyrosine kinase receptor TrkA. This ... darren broughWebUsing in vitro assays, we find that HGF cooperates with nerve growth factor (NGF) in enhancing the axonal growth rate of dorsal root ganglion (DRG) sensory neurons. In … darren bucknall rawcliffeWebhigh affinity nerve growth factor receptor GeneRIFs: Gene References Into Functions NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway. Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells. bison polymax high tackWebNerve growth factor (NGF) interacts with a low-affinity NGF receptor (LNGFR) and a high-affinity Trk receptor in the paracrine regulation of human prostate growth. Both the LNGFR and the Trk receptor localize to the epithelia of the normal prostate. darren bullough