Gstp1 advanced science

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August undefined, 2024

WebFeb 10, 2024 · GSTP1 actively protects cells from carcinogens and electrophilic compounds (27,28). It has been suggested that GSTP1 also protects cells from oxidants and electrophilic-mediated genomic damage … WebMar 25, 2024 · Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex GSTP proteins are metabolic enzymes involved in the removal of oxidative stress and intracellular signaling and also have inhibitory effects on JNK activity. However, the functions of Gstp proteins in the developing brain are unknown.

Entry - *134660 - GLUTATHIONE S-TRANSFERASE, PI; GSTP1

WebJan 29, 2024 · The clinical significance of GSTP1 was evaluated. Analysis of 15 GST isoforms of human lung cancer using the TCGA dataset showed GSTP1, GSTA2, … WebGSTP1 rs1695 (313 A>G, Ile105Val) is a widely studied polymorphism of GSTP1 in which guanine (G) replaces adenine (A) at 313 bases of exon 5 in the GSTP1 coding region, … debating the text of the word of god

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WebApr 1, 2024 · Therefore, GSTP 1-1 is an important target in cancer therapy, and many GST inhibitors have been reported. We had previously developed an irreversible inhibitor, GS-ESF, as an effective GST inhibitor; however, its cellular permeability was too low for it to be used in inhibiting intracellular GST. Web100042625 Ensembl ENSG00000084207 n/a UniProt P09211 n/a RefSeq (mRNA) NM_000852 XM_036155425 RefSeq (protein) NP_000843 n/a Location (UCSC) Chr 11: 67.58 – 67.59 Mb n/a PubMed search Wikidata … WebApr 14, 2024 · Apart from its catalytic detoxifying role, GSTP1 is involved in the process of glutathionylation, as well as regulation of redox-dependent apoptotic signaling ( Pljesa-Ercegovac et al., 2024 ). Regarding glutathionylation, it represents the posttranslational modification of protein thiol groups by the formation of mixed disulfides with glutathione. fearless lionheart

Glutathione S-transferase P1 (GSTP1) directly influences

Glutathione Transferase P1 - an overview ScienceDirect …

WebMar 14, 2024 · Search term. Search Advanced search for tests. GTR Home > Genes > GSTP1. GSTP1 glutathione S -transferase pi 1 Gene ID: 2950, updated on 14-Mar-2024 … WebJul 10, 2014 · GSTP1 protein expression was evaluated by western blotting, with complete loss of GSTP1 expression confirmed in shRNA construct … fearless lifeWebGSTP1 Inhibits LPS-Induced Inflammatory Response Through Regulating Autophagy in THP-1 Cells. The Impact of Beta-Catenin and glutathione-S-transferase Gene Polymorphisms on the Treatment Results and Survival of Multiple Myeloma Patients. debating third speaker template

"WebIn the current study, we found a novel mechanism by which GSTP1 protects human breast cancer cells from adriamycin (ADR)-induced cell death and contributes to the drug resistance. GSTP1 protein level is very low in human breast cancer cell line MCF-7 but is high in ADR-resistant MCF-7/ADR cells. " - Gstp1 advanced science

Gstp1 advanced science

Glutathione S-transferase pi1 promotes tumorigenicity in

WebGlutathione S-transferase Pi 1 (GSTP1) is an enzyme with an important antioxidant role and is encoded for by the GSTP1 gene. Glutathione is an important antioxidant molecule …

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WebJul 1, 2008 · GSTP1 expression and clinicopathological parameters of breast cancers. Of the 62 breast tumors, 35 were found to be GSTP1 positive. There was a significant (p < 0.05) association between GSTP1 positive expression and large tumor size or clinical cancer stage, as well as between GSTP1 methylation and GSTP1 negative expression. … WebJan 23, 2007 · UniProt P09211 · GSTP1_HUMAN Protein Glutathione S-transferase P Gene GSTP1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 210 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Add a publication Entry feedback Function

WebMar 27, 2024 · Among subjects without cancer, we found a significant correlation between participant age and GSTP1expression. Furthermore, the expression of GSTP1was significantly correlated with the number of cigarettes smoked per day, duration of tobacco use, and FTCD. WebGlutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti‑oxidative damage, and the occurrence of various diseases.

WebJun 11, 2024 · • Gstp1 expression is elevated in lung CSC cells which can be further increased upon treatment with a panel of chemotherapy drugs. • Gstp1 confers cisplatin … WebGSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux Redox Biol. 2024 Feb 27;61:102635. doi: 10.1016/j.redox.2024.102635. Online ahead of …

WebAssociation of GSTP1 Val105Ile polymorphism with breast cancer risk. Ten studies including 3,233 cases and 3,246 controls studied the association between GSTP1 Val105Ile (rs1695) polymorphism and breast cancer. 20,23–24,27,29–32,34,36 In the allelic model, our meta-analysis showed that GSTP1 Val105Ile (rs1695) polymorphism was not associated with …

WebOct 15, 2005 · GSTP1 is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles with glutathione in the process of detoxification. GSTP1 is widely overexpressed in colorectal cancer, from aberrant crypt foci to advanced carcinomas. debating the right to healthcareWebGSTP1; glutathione S-transferase pi 1; Description Glutathione S-transferases are a family of enzymes that play an important role in detoxification by catalyzing the … fearless lionheart lyricsWebGSTP1 is an enzyme that decreases oxidative damage in cells by catalyzing the conjugation of toxic compounds to glutathione. Promoter hypermethylation and silencing of GSTP1 … fearless liveloud chordsWebGSTP1 gene is located on chromosome 11q13 and is expressed in normal epithelial cells, such as cardiovascular system. 21 An A to G transition in codon 105 of GSTP1 enzyme leads to the substitution of isoleucine (Ile) to valine (Val) amino acids (Rs 1625). 22,23 This alteration affects the enzyme activity compared with the wild-type. debating thomas jefferson and slaveryWebApr 1, 2024 · Platinum-based chemotherapy regimens have been proven to be effective in various cancers; however, considerable toxicities may develop and can even lead to treatment discontinuation. Diverse factors may influence adverse treatment events, with pharmacogenetic variations being one prime example. Polymorphisms within the … fearless lionheart songWebGlutathione S-transferase Pi 1 (GSTP1) is an enzyme with an important antioxidant role and is encoded for by the GSTP1 gene. Glutathione is an important antioxidant molecule which readily neutralizes reactive oxygen species, a major cause of … debating tips and tricksWebFeb 1, 2024 · Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors Scientists unveiled that GSTP1 was upregulated in lung CSCs and supports tumor self-renewal, metastasis, and resistance to targeted tyrosine kinase inhibitors of lung adenocarcinoma both in vitro and in vivo. … debating topics about the media