WebDec 1, 2010 · F-box– and WD repeat domain–containing 7 (Fbxw7; also known as Fbw7, SEL-10, hCdc4, and hAgo) is a member of the F-box protein family that was initially identified as a negative regulator of LIN-12–mediated (Notch-mediated) signaling in Caenorhabditis elegans by genetic analysis (5, 6). WebApr 6, 2024 · FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in cancer. ... M. J. et al. FBXW7 and NOTCH1 mutations in childhood T …
Fbw7 Isoform Interaction Contributes to Cyclin E Proteolysis
WebMar 3, 2024 · Background: The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation … WebApr 6, 2024 · FBXW7 (F-box with seven tandem WD40; also known as Fbw7, Sel-10, hCdc4, hAgo, or Archipelago), encoded by the gene FBXW7 (loci, 4q31q.3), was first isolated as Cdc4 in budding yeast. The gene comprises 4 untranslated regions (UTRs) and 13 coding exons, which altogether define the substrate specificity of FBXW7, primarily … markiplier interactive videos
FBW7 in hematological tumors (Review) - Spandidos Publications
Web50754 Ensembl ENSG00000109670 ENSMUSG00000028086 UniProt Q969H0 Q8VBV4 RefSeq (mRNA) NM_001013415 NM_001257069 NM_018315 NM_033632 NM_001349798 NM_001177773 … Web研究背景FBXW7也称 FBW7,是F-box蛋白家族成员,为SCF(Skp-Cullin-F-box)泛素连接酶体系的靶蛋白识别组分。 ... FBXW7促进ENO1通过蛋白酶体途径降解1)蛋白质免疫共沉淀检测结果显示FBXW7和ENO1存在相互结合的作用。2)放线菌酮示踪实验结果显示FBXW7缺失延长ENO1蛋白的半衰期 ... WebThe SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys … markiplier in space path